{"id":3425,"date":"2026-05-27T12:45:10","date_gmt":"2026-05-27T12:45:10","guid":{"rendered":"https:\/\/ebram.com\/?p=3425"},"modified":"2026-05-27T12:46:04","modified_gmt":"2026-05-27T12:46:04","slug":"vitamina-d-e-doencas-cardiovasculares-o-que-a-ciencia-diz-e-como-o-laboratorio-pode-ajudar","status":"publish","type":"post","link":"https:\/\/ebram.com\/en\/vitamina-d-e-doencas-cardiovasculares-o-que-a-ciencia-diz-e-como-o-laboratorio-pode-ajudar\/","title":{"rendered":"Vitamin D and Cardiovascular Diseases: What Science Says and How the Lab Can Help"},"content":{"rendered":"<p>Cardiovascular diseases (CVDs) remain the leading cause of death worldwide. High blood pressure, acute myocardial infarction, heart failure, and coronary artery disease account for millions of cases each year. But one important piece of this puzzle is still underestimated in clinical practice: vitamin D deficiency.<\/p>\n<p>In this article, we explain what the latest scientific research reveals about the relationship between vitamin D and cardiovascular health, and how the laboratory plays a strategic role in this equation.<\/p>\n<p><b>What is vitamin D, and why is it so important?<\/b><\/p>\n<p>Vitamin D goes far beyond bone health. It is considered a steroid hormone with a broad spectrum of action in the human body, acting through the binding of its active metabolite, 1\u03b1,25-di-hydroxyvitamin D, to receptors (VDR) present in virtually all cells of the body, including cardiomyocytes and vascular smooth muscle cells.<\/p>\n<p>Microarray studies indicate that this active form of vitamin D has more than 900 potential target genes, corresponding to approximately 3% of the human genome. Its effects range from regulating calcium and phosphorus metabolism to controlling blood pressure, modulating the immune system, and participating in processes of cell proliferation and differentiation.<\/p>\n<p><b>A global shortcoming, including in Brazil<\/b><\/p>\n<p>Epidemiological data show that a significant portion of the world's population has inadequate serum levels of vitamin D, regardless of age, ethnicity, or geographic location.<\/p>\n<p>Brazil is among the countries with disability rates exceeding 50%, an alarming figure considering the potential of vitamin D synthesized through sun exposure. Among the main risk factors are:<\/p>\n<ul>\n<li>Lifestyle <i>indoor<\/i> (little sun exposure)<\/li>\n<li>Excessive use of sunscreen<\/li>\n<li>Advanced age<\/li>\n<li>Obesity<\/li>\n<li>Smoking<\/li>\n<li>Dark skin (greater competition among melanin molecules for photons of radiation)<\/li>\n<li>Kidney and liver diseases<\/li>\n<li>Intestinal malabsorption<\/li>\n<\/ul>\n<p><b>Vitamin D and Cardiovascular Disease: What Science Reveals<\/b><\/p>\n<p><b>High Blood Pressure<\/b><\/p>\n<p>Vitamin D acts by inhibiting the gene expression of renin, the central enzyme of the renin-angiotensin-aldosterone system (RAAS), thereby reducing its synthesis and preventing overstimulation of this system. Population-based studies such as NHANES-III (12,644 Americans) have shown that systolic blood pressure and pulse pressure are inversely correlated with levels of 25-hydroxyvitamin D. Studies in Brazil involving elderly hypertensive patients have confirmed this association.<\/p>\n<p><b>Diabetes mellitus<\/b><\/p>\n<p>Vitamin D plays a role in pancreatic beta cell function, insulin sensitivity, and the regulation of calcium flux across cell membranes. Observational studies indicate that the incidence of type 1 diabetes is higher in countries at higher latitudes and during the winter months, when there is less sun exposure. For type 2 diabetes, research links low vitamin D levels to insulin resistance and beta cell dysfunction.<\/p>\n<p><b>Coronary Artery Disease (CAD)<\/b><\/p>\n<p>There is evidence that vitamin D deficiency predisposes patients to recurrent adverse cardiac events and is associated with the number of affected coronary arteries, complications of acute myocardial infarction (AMI), and cardiac remodeling. A multicenter study of 239 patients with acute coronary syndrome revealed that 96% had low vitamin D levels at hospital admission. Another study found that patients with vitamin D levels below 10 ng\/mL had an in-hospital cardiovascular mortality rate of 24%, compared with 4.9% among the others.<\/p>\n<p><b>Heart Failure (HF)<\/b><\/p>\n<p>Vitamin D deficiency is associated with higher levels of BNP (a marker of cardiac stress), a higher rate of hospitalization for heart failure, and higher all-cause mortality. Recent studies have reported that, in patients with established heart failure and vitamin D deficiency, vitamin supplementation is associated with improved survival.<\/p>\n<p><b>Statin-induced myalgia<\/b><\/p>\n<p>Statins are cornerstones of cardiovascular prevention, but myalgia is a common side effect that affects treatment adherence. Studies have found that vitamin D deficiency is associated with a higher prevalence of this side effect. A cutoff value of 15 ng\/mL was identified as a risk predictor for the onset of myalgia in statin users, underscoring the importance of laboratory monitoring in these patients.<\/p>\n<p><b>The Role of the Laboratory: Why Test for Vitamin D?<\/b><\/p>\n<p>Given all these associations, vitamin D testing becomes a strategic tool in the prevention and monitoring of cardiovascular diseases. The test allows for:<\/p>\n<ul>\n<li>Identify at-risk patients before complications develop<\/li>\n<li>Monitoring the response to vitamin supplementation<\/li>\n<li>To supplement the evaluation of patients with hypertension, diabetes, heart failure, and statin use<\/li>\n<li>Assess at-risk populations: older adults, obese individuals, patients with chronic kidney disease, and people with diabetes<\/li>\n<\/ul>\n<p><b>QUIMIVIT D \u2014 Vitamin D from Ebram: delivers reliable results and has a wide range of applications.<\/b><\/p>\n<p>To ensure that laboratories can offer this test with high quality, speed, and cost-effectiveness, Ebram has developed the <a href=\"https:\/\/ebram.com\/en\/reagente\/turbidimetria\/#vitamina-d\">QUIMIVIT D \u2014 Vitamin D<\/a>, a reagent for the quantitative determination of 25-OH vitamin D using the latex immunoturbidimetric method.<\/p>\n<p><b>Why does QUIMIVIT D stand out?<\/b><\/p>\n<p>No need for specific, high-cost equipment. The reagent is compatible with automatic biochemical analyzers\u2014from the simplest to the most robust\u2014eliminating the need to rely on partnerships with support laboratories or make heavy investments in equipment.<\/p>\n<p>Results in less than 10 minutes. The speed with which results are released (reduced turnaround time) is a key advantage for both laboratory operations and the patient experience.<\/p>\n<p>Wide analytical range: 7.6 to 147.7 ng\/mL. Suitable for covering everything from cases of severe deficiency to supplementation monitoring.<\/p>\n<p>Accuracy and traceability. The product correlates with the LC-MS\/MS reference method, is traceable to NIST, and meets the performance criteria defined by the DEQAS advisory panel, with excellent accuracy (CV &lt; 5% at 30 ng\/mL).<\/p>\n<p>For human and veterinary use.<a href=\"https:\/\/ebram.com\/en\/reagente\/turbidimetria\/#vitamina-d\"> QUIMIVIT D<\/a> It also identifies vitamins D2 and D3 and is versatile enough for use with both human and animal samples.<\/p>\n<p>No interference from biotin. An important safety consideration when interpreting results.<\/p>\n<p>Would you like to learn more about QUIMIVIT D? Contact the Ebram team and request more information about the product<\/p>\n<p dir=\"ltr\">Customer Service: 0800 500 2424 | Email:\u00a0<a href=\"mailto:sac@ebram.com\" target=\"_blank\" rel=\"noopener\" data-slider-ignore-autobinding=\"true\">sac@ebram.com<\/a>.<\/p>\n<p dir=\"ltr\">Sales Department: 11 2291-2811 |  Email:\u00a0<a href=\"mailto:vendas@ebram.com\" target=\"_blank\" rel=\"noopener\" data-slider-ignore-autobinding=\"true\"><u>vendas@ebram.com<\/u><\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>As doen\u00e7as cardiovasculares (DCVs) continuam sendo a principal causa de mortalidade em todo o mundo. Hipertens\u00e3o arterial, infarto agudo do mioc\u00e1rdio, insufici\u00eancia card\u00edaca e doen\u00e7a arterial coronariana somam milh\u00f5es de casos anualmente. Mas uma pe\u00e7a importante desse quebra-cabe\u00e7a ainda \u00e9 subestimada na pr\u00e1tica cl\u00ednica: a defici\u00eancia de vitamina D. Neste artigo, explicamos o que a [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":3426,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3425","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-pt"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Vitamina D e Doen\u00e7as Cardiovasculares: qual a rela\u00e7\u00e3o<\/title>\n<meta name=\"description\" content=\"Entenda a rela\u00e7\u00e3o entre vitamina D e doen\u00e7as cardiovasculares e veja como o laborat\u00f3rio pode atuar na preven\u00e7\u00e3o e monitoramento cl\u00ednico\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ebram.com\/en\/vitamina-d-e-doencas-cardiovasculares-o-que-a-ciencia-diz-e-como-o-laboratorio-pode-ajudar\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vitamina D e Doen\u00e7as Cardiovasculares: qual a rela\u00e7\u00e3o\" \/>\n<meta property=\"og:description\" content=\"Entenda a rela\u00e7\u00e3o entre vitamina D e doen\u00e7as cardiovasculares e veja como o laborat\u00f3rio pode atuar na preven\u00e7\u00e3o e monitoramento cl\u00ednico\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ebram.com\/en\/vitamina-d-e-doencas-cardiovasculares-o-que-a-ciencia-diz-e-como-o-laboratorio-pode-ajudar\/\" \/>\n<meta property=\"og:site_name\" content=\"Ebram - 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